By Yves Pommier (Ed.),Yves Pommier

DNA topoisomerases symbolize an important family members of DNA processing enzymes and various topoisomerase inhibitors are used clinically for the remedy of varied human cancers. Novels medications are in scientific improvement either opposed to variety I and kind II topoisomerases. The ebook will comprise simple biochemical and structural studies for the cancer-relevant topoisomerases. it's going to describe how topoisomerase dysfunctions can harm the genome and elevate the danger of cancers, and the involvement of topoisomerases in programmed cellphone loss of life. The publication also will current some of the topoisomerase inhibitors in medical use and improvement and their molecular and mobile mechanisms of action.

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DNA Topoisomerases and Cancer (Cancer Drug Discovery and Development) by Yves Pommier (Ed.),Yves Pommier


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