Advanced Practical Medicinal Chemistry by Ashutosh Kar

By Ashutosh Kar

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These are usually dealt within a specific way, and hence could be the possible outcome of last reactions in the synthesis. They may also be carried out successfully either by means of aforesaid construction reactions or through functional alteration reactions. However, the latter operation(s) exclusively alter the ‘functional moieties’ without affecting the basic carbon-carbon skeleton. The exact nature of the functional moieties present in the target-drug-molecule may, therefore, guide one precisely about what chemical reactions might be opted for.

A) that construction reactions essentially establish carbon-carbon skeletons (bonds) in a target-drug-molecules ; those reactions that specifically cleave carbon-carbon skeletons (bonds) are usually termed as ‘fragmentation reactions’. In other words, the former enjoys its existence and importance to build up desired C—C skeletons and, therefore, are absolutely necessary in a synthesis ; however, the latter causes degradation or split-up of C—C skeletons and they also possess certain vital synthetic utility.

New York, 1989. P-IV\C:\N-ADV\CH2-1 DRUG SYNTHESIS 17 termed as the construction reactions, is regarded as the backbone and obviously the most crucial step in designing a synthesis. (b) Inclusion of Functional Moieties. Invariably, the necessary and required functional groups are most carefully and strategically positioned at various specific locations on the proposed target skeleton. These are usually dealt within a specific way, and hence could be the possible outcome of last reactions in the synthesis.

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